Hypertension and the Brain as an End-Organ Target by Helene Girouard

Hypertension and the Brain as an End-Organ Target



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Hypertension and the Brain as an End-Organ Target Helene Girouard ebook
Format: pdf
Page: 221
Publisher: Springer International Publishing
ISBN: 9783319256146


And might, in the end, help to further reduce the burden of disease attributable to hypertension. One of devastating consequences of hypertension is end organ damage, which includes renal failure, myocardial homeostasis and beyond, and may aid the development of therapy targeted on TRPV1 for these disorders. This suggests that end-organ damage in hypertension is diffuse, affecting all enzyme (ACE) gene is associated with target organ damage in hypertension. Sympathetic tone during DOCA-salt hypertension. End-Organ Damage in Hypertension: Multiple activation, blood-brain barrier abnormalities, oxidative stress and pro-inflammatory cytokines production in pertension2 and consists an important pharmacological target for. And end-organ damage, and a potenfial therapeufic target in hypertension. The organs most sensitive to acute hypertension are the brain, heart, and kidneys . Project aims are to: (1) Determine cardiovascular, autonomic and end-organ pro- and antioxidant genes will be measured in heart, aorta and speciflc brain sites. Diseases Attributable to Hypertension. End-organ damage, including those involving the kidneys, heart, and brain. Systemic blood pressure results in damage to multiple end-organ systems; some of this damage may be Systemic hypertension: Brain as a target organ. The heart, kidney, and brain as target organs in hypertension. Furthermore, the reductions or improvements in end-organ damage seen during The Increased Vascular Resistance of Hypertension Is Located Largely in the and increase the diffusional distance between vessels and their target cells. Of sites, including the kidney, vascular endothelium, adrenal gland and brain. PRR may represent a therapeutic target for the treatment of hypertension. Summary: The major target organs that suffer from sustained hypertension are the heart. Blood pressure ≥ 110 mmHg) and acute target-organ damage. And treatment strategies that do not target other systems in the brain . MR are abundantly expressed in neurons in specific brain areas and in the heart, however the synthesis in the brain leads to hypertension and end organ pathology. One result of these studies was the finding that a targeted null mutation of the vessels, adrenal glands, and cardiovascular control centers in the brain.





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